THE RADAR SITE:

RADAR INFORMATION:
Overview
News and Events

RADAR SERVICES:
Training Courses
Consulting
Software

RADAR MEMBERS

RADAR Home Page



RADAR RESOURCES:

RADAR ON-LINE DATA:
On-Line Decay Data
On-Line Kinetic Data
On-Line Model Dose Factors

INTERNAL SOURCES:
Occupational Dose Factors
Nuclear Medicine:
Diagnosis
Therapy

EXTERNAL SOURCES:
External Point Source
Beta Dose to Skin
Immersion in Air
Ground Contamination
Medical Sources
VARSKIN code

RADAR SOFTWARE

DOSE-RELATED LITERATURE

MEDICAL PROCEDURE DOSE CALCULATOR AND RISK LANGUAGE GENERATOR




RADAR DOCUMENTS:
System Overview
Internal Dose System
External Dose System
Decay Data
Kinetic Data
Phantoms
Risk Models


The OLINDA/EXM Personal Computer Code


The OLINDA/EXM personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004. OLINDA/EXM, which stands for Organ Level INternal Dose Assessment/EXponential Modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on user-supplied biokinetic data, to support such calculations.

The OLINDA code was written by Michael Stabin PhD, CHP, who also wrote the MIRDOSE 3.0 and 3.1 codes, which were widely used in the radiopharmaceutical industry and research community for internal dose calculations for radiopharmaceuticals. MIRDOSE was relied upon for a number of years and was been used by thousands of medical, safety, and regulatory professionals. OLINDA version 1 used basically the same calculational algorithms as MIRDOSE, with some updates, including:
  • Nearly 600 new radionuclides (including alpha emitters)
  • New organ phantoms
  • A revised and improved bone model
  • A code for performing kinetic analysis of biokinetic data (EXM, written by Drs. Richard Sparks and Eric Crowe of CDE, Inc.)
  • The ability to modify organ masses to patient-specific values

Version 2 now has:
  • Over 1000 radionuclides (including alpha emitters)
  • Next generation, voxel-based realistic phantoms for adults, children and pregnant women.
  • Voxel-based realistic phantoms for 3 mouse, 5 rat, and 2 dog models.
  • The ability to modify organ masses to patient-specific values
  • The ability assign activity to the walls of hollow organs
OLINDA/EXM runs on Windows-2000 or Windows-XP-based personal computers, with 256 MB RAM, and 100 MB free space on the primary hard disk.

OLINDA/EXM version 1 was extensively beta-tested prior to release, and has been granted a FDA 510(k) - K03396 by the US Food and Drug Administration as a software device. Appropriate approvals for version 2 are being obtained.

Method
  • OLINDA/EXM uses the RADAR method of dose calculation (Stabin and Siegel, Health Phys. 85(3):294-310, 2003) and the dose conversion factors as supplied on the RADAR web site (www.doseinfo-radar.com). This site is regularly visited about 500 times per month by investigators from around the world for dose-related information.
  • The OLINDA/EXM code uses essential data from this site to automate dose calculations for nuclear medicine patients. Doses to 29 different organs in SI or traditional units are provided for 10 whole body phantoms and 5 specific organ phantoms (peritoneal cavity, prostate gland, head and brain, kidney, and spheres).
  • Users need only specify which radionuclide is to be used (over 1000 nuclides included), which body model(s) are of interest (adult male, adult female, children, and women at different stages of pregnancy), and enter parameters which describe the biokinetics of the radiopharmaceutical within the body.
  • Results are displayed on screen and may be saved to disk or printed.
Obtaining the Software

The code is available from the Hermes Medical web site .

Support

A detailed instruction manual including implementation tests is supplied with the software. The implementation tests describe a series of sample problems that can be run to ensure the correct installation of the software. A detailed instruction manual is supplied with the code, and some on-screen help is provided as well. You may also view two brief demonstration videos of OLINDA/EXM at this page . Active support for use of the code is also provided via phone, email, regular mail, or fax. Please contact Michael Stabin at Vanderbilt University to learn more about OLINDA/EXM and what it can do for you.

Michael G. Stabin, PhD, CHP
Assistant Professor of Radiology and Radiological Sciences
Department of Radiology and Radiological Sciences
Vanderbilt University
1161 21st Avenue South
Nashville, TN 37232-2675
Phone (615) 343-0068
Fax (615) 322-3764
e-mail michael.g.stabin@vanderbilt.edu